Reproductive Homeostasis and Senescence in Drosophila melanogaster
| Autor: | James W. Curtsinger |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Senescence Aging media_common.quotation_subject Fertility 03 medical and health sciences 0302 clinical medicine Medicine Animals Life history media_common biology business.industry Reproduction fungi Fecundity biology.organism_classification Cell biology Adult life 030104 developmental biology Drosophila melanogaster Models Animal Female Geriatrics and Gerontology business 030217 neurology & neurosurgery Homeostasis |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences. 74(10) |
| ISSN: | 1758-535X |
| Popis: | The homeostatic properties of reproduction in aging female Drosophila melanogaster are investigated. Classic studies based on cohort analysis suggest that homeostatic capacity declines gradually as daily oviposition rates decline in aging flies. Analysis at the level of individuals gives a very different picture: reproductive homeostasis remains relatively constant for most of adult life until a critical point when oviposition either ceases entirely or continues in dysregulated fashion. The collapse of homeostatic capacity is abrupt. Enhanced homeostasis is associated with increased lifetime fecundity and improved prospects for survival. The fractal concept of lacunarity can be used to parameterize the “roughness” of individual fecundity trajectories and is inversely related to homeostatic capacity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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