Isolated granulocytic sarcoma of the small intestine successfully treated with chemotherapy and bone marrow transplantation
| Autor: | Masanao Teramura, Yukiko Kitagawa, Shinichiro Mori, Yuichi Sameshima, Toshiko Motoji, Shinpei Ogawa, Shingo Kameoka, Michihiko Masuda, Akihiro Masuda, Hiroko Shiozaki |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Myeloid medicine.medical_treatment Antineoplastic Agents Myelogenous hemic and lymphatic diseases Internal medicine Intestinal Neoplasms Intestine Small medicine Humans Sarcoma Myeloid Bone Marrow Transplantation Chemotherapy Hematology business.industry medicine.disease Radiography Transplantation Leukemia medicine.anatomical_structure Female Bone marrow Sarcoma business |
| Zdroj: | International Journal of Hematology. 87:410-413 |
| ISSN: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-008-0067-6 |
| Popis: | Isolated primary granulocytic sarcoma is a rare disease that presents as an extramedullary tumor of myeloid lineage cells. Most patients subsequently develop acute myelogenous leukemia (AML) within a short period, and their prognosis is poor. Herein, we report the case of a 33-year-old woman with a primary isolated granulocytic sarcoma which originated in the small intestine. After she recovered from surgery, she received intensive chemotherapy equivalent to that for AML, followed by allogeneic bone marrow transplantation from an HLA-matched, unrelated donor. Four years after the transplantation, she remains in complete remission without graft-versus-host disease or any other symptoms. This case illustrates the effectiveness of our therapeutic strategy for isolated granulocytic sarcoma, not only with surgical resection of the tumor and intensive chemotherapy equivalent to that for AML, but also with allogeneic bone marrow transplantation, performed while no sign of AML is observed. |
| Databáze: | OpenAIRE |
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