Biotechnology and the treatment of addictive disorders: new opportunities
Autor: | Jane B. Acri, Frank Vocci, Ahmed Elkashef, Jamie Biswas |
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Rok vydání: | 2007 |
Předmět: |
Drug
medicine.medical_specialty Substance-Related Disorders media_common.quotation_subject medicine.medical_treatment Amphetamine-Related Disorders Disease Preclinical research Cocaine-Related Disorders Pharmacotherapy Medicine Humans Immunologic Factors Pharmacology (medical) Psychiatry media_common Pharmacology Vaccines business.industry Addiction Antibodies Monoclonal General Medicine Tobacco Use Disorder Abstinence Stimulant Molecular targets Immunotherapy business Biotechnology |
Zdroj: | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 21(4) |
ISSN: | 1173-8804 |
Popis: | Addiction is a chronic relapsing illness with onset typically occurring in the early teenage years, followed by cycles of drug use and abstinence. The disease is mitigated by complex interactions between genes and environment. Viewed as such, the treatment of addiction could span the whole lifetime of the patient and, ideally, should be tailored to the illness cycle. The search for effective treatments has intensified recently due to our better understanding of the underlying neurobiologic mechanisms contributing to drug use and relapse. The three main types of treatment are behavioral, pharmacologic and, more recently, immunologic therapies. Vaccines and monoclonal antibodies are being developed mainly for stimulant use disorders and nicotine addiction. In addition, new molecular targets identified by preclinical research have shown promise and are awaiting proof-of-concept studies in humans. The main focus of this review is on the development of immunotherapy for stimulants and nicotine addiction as a model highlighting the current status of the science and potential emerging discoveries and development. |
Databáze: | OpenAIRE |
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