Studies on the CEA-like substance in gastric juice
| Autor: | Takashi Suzuki, Akira Yachi, Yoshikazu Akahonai, Takeo Wada, Makoto Kawaharada, Shozō Fukuya, Minoru Sudo |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
medicine.medical_specialty
Early cancer Gastric Juice Atrophic gastritis business.industry Gastroenterology Radioimmunoassay Intestinal metaplasia Hepatology medicine.disease Gastric secretions digestive system diseases Early Gastric Cancer Carcinoembryonic Antigen Surgical oncology Stomach Neoplasms Internal medicine Gastritis medicine Humans business |
| Zdroj: | Gastroenterologia Japonica. 13(1) |
| ISSN: | 0435-1339 |
| Popis: | Concentration and heterogeneity of CEA-like substance in gastric juice were studied using radioimmunoassay. Statistically significant increase of CEA-like substance in gastric juice was found in advanced atrophic gastritis (P less than 0.01), early gastric cancer (P less than 0.05) and advanced gastric cancer (P less than 0.01) as compared with normal subjects. In cases with atrophic gastritis with a high degree of intestinal metaplasia, the concentrations above 300 microgram/dl were noticed. The results indicate that increased concentrations of CEA-like substance in gastric secretions may strongly suggest the presence of a marked intestinal metaplasia and/or cancerous changes of gastric mucosae, including the early cancer. The distribution of CEA activity in gel filtration fractions of gastric juice was compared using kits of two different radioimmunoassay systems. The patterns of CEA activities were different between the two different kits used, but the main peaks were located in the fractions with the molecular weight of 20x10(4) daltons corresponding to that of serum CEA. It is considered, however, that the CEA-like substance in gastric juice specimens may be more or less heterogenous when any of the methods is used. |
| Databáze: | OpenAIRE |
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