Effect of Central Antileptin Antibody on the Onset of Female Rat Puberty
| Autor: | Kenneth McCormick, Daoxin Zheng, Yanfeng Fan, Ruimin Chen, Rongxian Xu, Gail J. Mick, Xiangquan Lin |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
lcsh:RC648-665 biology business.industry Leptin digestive oral and skin physiology lcsh:RJ1-570 lcsh:Pediatrics Body weight Group A lcsh:Diseases of the endocrine glands. Clinical endocrinology Group B Immunoglobulin G Endocrinology Internal medicine Serum leptin medicine biology.protein Antibody business Luteinizing hormone hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | International Journal of Pediatric Endocrinology, Vol 2009 (2009) International Journal of Pediatric Endocrinology, Vol 2009, Iss 1, p 194807 (2009) International Journal of Pediatric Endocrinology |
| ISSN: | 1687-9856 |
| DOI: | 10.1186/1687-9856-2009-194807 |
| Popis: | The effect of intracerebroventricular (ICV) antileptin antibody on the onset of puberty in the female rat and the relationship between serum leptin, luteinizing hormone (LH), and body weight were investigated. Antileptin antibody (group A) was infused ICV from days 23–36 in prepubertal female rats whereas the control (group B) received ICV goat immunoglobulin G (IgG). In the antileptin group, mean day of vaginal opening (VO) was postponed (day 34 versus day 30, ). Body weight trended higher after 30 days in the antileptin group but not significantly. However, there was no difference in serum leptin and LH between the two groups on the day of VO. Serum leptin was relatively constant from day 23 through day 31 and did not correlate with LH . These studies demonstrate that central leptin promotes the onset of female rat puberty as evidenced by VO. Finally, central leptin impacts female rat pubertal onset in distinction from serum leptin and body weight. |
| Databáze: | OpenAIRE |
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