TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in zebrafish
Autor: | Mary G. Goll, Cheng Li, Jasmine Alexandra Fels, Bernard Thisse, Christine Thisse, Jonathan Fillatre, Jean-Daniel Fauny |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Vgll4
Taz QH301-705.5 Science Hippo pathway Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Transcription (biology) Left-Right Organizer Ciliogenesis Transcriptional regulation Animals Biology (General) Transcription factor Zebrafish 030304 developmental biology Body Patterning 0303 health sciences Hippo signaling pathway General Immunology and Microbiology General Neuroscience Gene Expression Regulation Developmental General Medicine biology.organism_classification Cell biology DNA methylation Medicine Left-Right asymmetry Yap Signal transduction 030217 neurology & neurosurgery Research Article Developmental Biology Signal Transduction Transcription Factors |
Zdroj: | eLife eLife, Vol 8 (2019) |
ISSN: | 2050-084X |
Popis: | In many vertebrates, establishment of Left-Right (LR) asymmetry results from the activity of a ciliated organ functioning as the LR Organizer (LRO). While regulation of the formation of this structure by major signaling pathways has been described, the transcriptional control of LRO formation is poorly understood. Using the zebrafish model, we show that the transcription factors and cofactors mediating or regulating the transcriptional outcome of the Hippo signaling pathway play a pivotal role in controlling the expression of genes essential to the formation of the LRO including ligands and receptors of signaling pathways involved in this process and most genes required for motile ciliogenesis. Moreover, the transcription cofactor, Vgll4l regulates epigenetic programming in LRO progenitors by controlling the expression of writers and readers of DNA methylation marks. Altogether, our study uncovers a novel and essential role for the transcriptional effectors and regulators of the Hippo pathway in establishing LR asymmetry. |
Databáze: | OpenAIRE |
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