Mycobacterial Dormancy Regulon Protein Rv2623 as a Novel Biomarker for the Diagnosis of Latent and Active Tuberculous Meningitis
| Autor: | Girdhar M. Taori, Rajpal S. Kashyap, Amit R. Nayak, Ruchika K. Jain, Hemant J. Purohit, Nitin H. Chandak, Milind S. Panchbhai, Hatim F. Daginawala, Aliabbas A. Husain |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Article Subject Adolescent Clinical Biochemistry urologic and male genital diseases Tuberculous meningitis Mycobacterium tuberculosis Bacterial Proteins Antigen Latent Tuberculosis Genetics medicine Humans Child Molecular Biology lcsh:R5-920 Latent tuberculosis biology business.industry Biochemistry (medical) Case-control study General Medicine Middle Aged Phosphate-Binding Proteins medicine.disease biology.organism_classification Regulon Case-Control Studies Tuberculosis Meningeal Immunology Biomarker (medicine) Dormancy Female Carrier Proteins lcsh:Medicine (General) business Biomarkers Research Article |
| Zdroj: | Disease Markers, Vol 35, Iss 5, Pp 311-316 (2013) Disease markers |
| ISSN: | 1875-8630 0278-0240 |
| DOI: | 10.1155/2013/309816 |
| Popis: | The present study was designed to investigate Rv2623 antigen, a major dormancy regulon protein ofMycobacterium tuberculosis(MTB) in CSF of suspected latent and active tuberculous meningitis (TBM) patients. A total of 100 CSF samples from TBM (n=31), suspected latent TBM (n=22), and suitable noninfectious control subjects (n=47) were collected and evaluated for Rv2623 antigen level using ELISA protocol. A significantly high (P<0.05) mean absorbance was observed in samples of suspected latent TBM and active TBM patients as compared to non-TBM control patients. However, no significant difference in Rv2623 level was observed between suspected latent TBM and TBM patients. Our preliminary findings suggest that Rv2623 may be useful as a potential biomarker for the diagnosis of the latent as well as active TBM infection. Futher evaluation of this biomarker in large number of samples is therefore needed to confirm the result. |
| Databáze: | OpenAIRE |
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