Estimated glomerular filtration rate is a marker of mortality in the European Scleroderma Trials and Research Group (EUSTAR) database
| Autor: | Gigante, Antonietta, Hoffmann-Vold, Anna-Maria, Fegatelli, Danilo Alunni, Gabrielli, Armando, Leodori, Giorgia, Coleiro, Bernard, De Santis, Maria, Dagna, Lorenzo, Alegre-Sancho, Juan Jose, Montecucco, Carlomaurizio, Carreira, Patricia E, Balbir-Gurman, Alexandra, Doria, Andrea, Riemekasten, Gabriela, Airò, Paolo, Distler, Jörg H W, Distler, Oliver, Rosato, Edoardo, EUSTAR collaborators |
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| Přispěvatelé: | University of Zurich |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine systemic sclerosis Scleroderma Renal Crisis Renal function 610 Medicine & health computer.software_genre Scleroderma 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatology Predictive Value of Tests Risk Factors medicine Humans Pharmacology (medical) In patient Risk factor 030203 arthritis & rheumatology EUSTAR Creatinine Scleroderma Systemic Database Proportional hazards model business.industry Incidence 10051 Rheumatology Clinic and Institute of Physical Medicine glomerular filtration rate scleroderma renal crisis Middle Aged medicine.disease Pulmonary hypertension Survival Rate 030104 developmental biology chemistry Female business computer Glomerular Filtration Rate |
| Popis: | Objectives The study aim was to evaluate the estimated glomerular filtration rate (eGFR), its association with clinical disease and its predictive ability with respect to mortality in SSc patients from the European Scleroderma Trials and Research Group (EUSTAR) database. Methods SSc patients from the EUSTAR database who had items required for the calculation of eGFR at a baseline visit and a second follow-up visit available were included. A cut-off eGFR value of 60 ml/min was chosen for all SSc patients, and 30 ml/min for those with scleroderma renal crisis (SRC). Cox regression and competing risk analysis were performed to evaluate the use of eGFR as a predictive factor of mortality. Results A total of 3650 SSc patients were included in this study. The median serum level of creatinine and the mean of eGFR were 0.8 mg/dl (interquartile range = 0.6–0.9) and 86.6 ± 23.7 ml/min, respectively. The eGFR was significantly lower in patients with pulmonary hypertension. Overall survival (OS) was significantly reduced in SSc patients with eGFR 30 ml/min and those with eGFR Conclusion eGFR represents a predictive risk factor for overall survival in SSc. The eGFR, however, does not represent a risk factor for death in SRC. |
| Databáze: | OpenAIRE |
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