Cellulose Acetate Butyrate: Ammonio Methacrylate Copolymer Blends as a Novel Coating in Osmotic Tablets
| Autor: | Roland Bodmeier, Rebaz Ali, Mathias Walther |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Osmosis
Pharmaceutical Science 02 engineering and technology Aquatic Science engineering.material 030226 pharmacology & pharmacy Excipients 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Coating Polymethacrylic Acids Plasticizers Drug Discovery Polymer chemistry Solubility Cellulose Ecology Evolution Behavior and Systematics chemistry.chemical_classification Ethanol Ecology Plasticizer General Medicine Polymer 021001 nanoscience & nanotechnology Phosphate Cellulose acetate Drug Liberation chemistry Chemical engineering engineering Polymer blend 0210 nano-technology Agronomy and Crop Science Tablets |
| Zdroj: | AAPS PharmSciTech. 19(1) |
| ISSN: | 1530-9932 |
| Popis: | The objective of this work was the preparation of osmotic tablets using polymer blends of cellulose acetate butyrate (CAB) or ethylcellulose with ammonio methacrylate copolymer (Eudragit® RL). The advantage of these coatings in comparison to the traditionally used cellulose acetate is their solubility in safer organic solvents like ethanol. Polymer films were characterized with respect to their water uptake, dry mass loss, and mechanical properties. The effect of the polymer blend ratio on drug release and on the rupture force of the coating was investigated. In addition, the effect of drug solubility and content, pH and agitation rate of the release medium, and coating level and plasticizer content on the release were studied. With increased Eudragit® RL content in the coating blends, higher medium uptake of the film was observed, resulting in shorter lag times and faster drug release from the osmotic tablets. Replacing ethylcellulose with cellulose acetate butyrate as a coating material led to shorter lag times and faster drug release due to increased film permeability. In addition, CAB-based films had a higher strength and flexibility. The drug release was osmotically controlled and decreased with increasing coating level. It increased with increased drug solubility, plasticizer content, change of buffer species (acetate > phosphate), and decreased coating level. Agitation rate and drug content had no effect on the drug release. A 20% w/w coating level was sufficient for the tablet to tolerate forces of more than five times of the gastric destructive force reported in literature. |
| Databáze: | OpenAIRE |
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