Influence of genetic variations in platelet glycoproteins and eNOS in the development of arterial ischaemia of lower limbs in type 2 diabetes mellitus patients

Autor:	Ema Ruivães, Virgínia Carvalhais, Flávio Oliveira, Bárbara Mesquita, Luís Bernardo Pina-Cabral, Maria Begoña Criado, Maria Céu Monteiro
Rok vydání:	2016
Předmět:	Male medicine.medical_specialty Genotype Nitric Oxide Synthase Type III Kozak consensus sequence 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Platelet membrane glycoprotein 03 medical and health sciences 0302 clinical medicine Gene Frequency Ischemia Enos Internal medicine Diabetes mellitus Humans Medicine Genetic Predisposition to Disease Orthopedics and Sports Medicine Platelet Podiatry Aged Aged 80 and over Polymorphism Genetic biology business.industry Type 2 Diabetes Mellitus Middle Aged biology.organism_classification medicine.disease Endocrinology Diabetes Mellitus Type 2 Lower Extremity Platelet Glycoprotein GPIb-IX Complex Cardiology Female business Complication Diabetic Angiopathies
Zdroj:	The Foot. 29:42-44
ISSN:	0958-2592
DOI:	10.1016/j.foot.2016.10.002
Popis:	Endothelial and platelet dysfunction increase the atherothrombotic risk in diabetes mellitus patients. Therefore, arterial ischaemia of lower limbs is an important complication in diabetes mellitus. In the present work, type 2 diabetic patients were classified by a podiatrist into presence or absence of arterial ischaemia of lower limbs. Several polymorphisms in platelet glycoproteins and eNOS genes were evaluated. Our results suggest that the -5CC genotype in Kozak sequence of GPIbα may be associated with a higher risk of developing arterial ischaemia of lower limbs in type 2 diabetes mellitus patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29aed4119ba1ec81d9651bf65356c48e https://doi.org/10.1016/j.foot.2016.10.002 Zobrazit plný text záznamu Full Text from ScienceDirect