Potentiation of antihypertensive therapy by use of chlorothiazide
| Autor: | Allen C. Bullock, J.B. Rochelle, Ralph V. Ford |
|---|---|
| Rok vydání: | 1958 |
| Předmět: |
medicine.medical_specialty
Control level Therapeutic regimen business.industry medicine.medical_treatment Chlorothiazide Clinical trial Acetazolamide Regimen Endocrinology Mean blood pressure Anesthesia Internal medicine Mecamylamine Hypertension medicine Diuretic business Antihypertensive Agents medicine.drug |
| Zdroj: | Journal of the American Medical Association. 168(4) |
| ISSN: | 0002-9955 |
| Popis: | Although chlorothiazide (Diuril) was initially introduced as an orally given diuretic, 1 subsequent clinical trial readily revealed this agent to possess significant antihypertensive properties. In 25 patients moderate hypertension hadbeen somewhat less than adequately controlled for a period of at least six months with Rauwolfia (Raudixin) alone. In another 25 patients it had been inadequately controlled for a similar period with a regimen of Rauwolfia and mecamylamine (Inversine). Chlorothiazide (500 mg. after breakfast and lunch) was added to the therapeutic regimen of each patient. In the first group of patients, the upright mean blood pressure was reduced from the control level of 131 mm. Hg to 109 mm. Hg (p |
| Databáze: | OpenAIRE |
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