Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites
| Autor: | Ery Odette Fukushima, Paskorn Muangphrom, Toshiya Muranaka, Hikaru Seki |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
0106 biological sciences
0301 basic medicine Plasmodium Artemisia annua Pharmaceutical Science Review Pharmacology 01 natural sciences 03 medical and health sciences Antimalarials Resistant parasites parasitic diseases Drug Discovery medicine Animals Humans Parasites Artemisinin Mode of action biology Mechanism (biology) business.industry Organic Chemistry biology.organism_classification medicine.disease Artemisinins Biotechnology Malaria 030104 developmental biology Drug development Metabolic Engineering Complementary and alternative medicine Molecular Medicine Artemisia business 010606 plant biology & botany medicine.drug |
| Zdroj: | Journal of Natural Medicines |
| ISSN: | 1340-3443 |
| DOI: | 10.1007/s11418-016-1008-y |
| Popis: | Malaria is a worldwide disease caused by Plasmodium parasites. A sesquiterpene endoperoxide artemisinin isolated from Artemisia annua was discovered and has been accepted for its use in artemisinin-based combinatorial therapies, as the most effective current antimalarial treatment. However, the quantity of this compound produced from the A. annua plant is very low, and the availability of artemisinin is insufficient to treat all infected patients. In addition, the emergence of artemisinin-resistant Plasmodium has been reported recently. Several techniques have been applied to enhance artemisinin availability, and studies related to its mode of action and the mechanism of resistance of malaria-causing parasites are ongoing. In this review, we summarize the application of modern technologies to improve the production of artemisinin, including our ongoing research on artemisinin biosynthetic genes in other Artemisia species. The current understanding of the mode of action of artemisinin as well as the mechanism of resistance against this compound in Plasmodium parasites is also presented. Finally, the current situation of malaria infection and the future direction of antimalarial drug development are discussed. |
| Databáze: | OpenAIRE |
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