Inhibition of cells producing antigen-dependent non-specific immunoglobulins by isologous anti-erythrocyte immunoglobulins

Autor:	E.I. Rubakova, V.G. Nesterenko, E. V. Sidorova, M.G. Agadjanian, T.B. Megrabian
Rok vydání:	1985
Předmět:	Immunosuppression Therapy Isoantigens Erythrocytes Sheep biology Chemistry Immunology Immunoglobulins Mice Inbred Strains Molecular biology Mice Immunoglobulin Idiotypes Antigen Non specific Homologous antigen biology.protein Animals Immunology and Allergy Antibody Antibody-Producing Cells Chickens
Zdroj:	Immunology Letters. 9:307-311
ISSN:	0165-2478
DOI:	10.1016/0165-2478(85)90054-9
Popis:	Mice injected with isologous cellulose-conjugated immunoglobulins containing antibodies to sheep red blood cells develop a specific unresponsiveness to the homologous antigen. It was shown that such animals demonstrate a sharp decrease not only in the number of antibody-forming cells but also in the number of cells secreting antigen-dependent non-specific immunoglobulins. The suppression of both processes is antigen-specific. It is suggested that the reduced appearance of cells forming antigen-dependent non-specific immunoglobulins is due to suppression either of hypothetic inductors or precursors of these cells, which resemble the precursors of antibody producers in their idiotypes. The presence of the common precursors of antibody- and antigen-dependent non-specific immunoglobulin-forming cells is an alternative possibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ab08706a1f6c37b3c736334a3c706e https://doi.org/10.1016/0165-2478(85)90054-9 Zobrazit plný text záznamu