Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma
| Autor: | Bong-Soo Park, Ji Hye Lee, Su-Bin Yu, In-Ryoung Kim, Nak-Eun Choi, Hyun-Kyung Kang, Hye Jin Kim, Hae-Mi Kang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
business.industry medicine.medical_treatment Autophagy stomatognathic diseases 03 medical and health sciences chemistry.chemical_compound Crosstalk (biology) 030104 developmental biology 0302 clinical medicine Oncology chemistry Apoptosis Cell culture 030220 oncology & carcinogenesis medicine Cancer research Basal cell business Adjuvant Survival rate Fisetin |
| Zdroj: | Journal of Cancer. 10:138-146 |
| ISSN: | 1837-9664 |
| Popis: | Fisetin (3,3-,4-,7-tetrahydroxyflavone), a naturally occurring flavonoid, has antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma (OSCC) has a 5-year survival rate lower than that of most other carcinomas, and can create functional and aesthetic problems for the patient. New therapies for OSCC are necessary, and treatment using plant-derived natural substances has recently become a trend. It has been suggested that autophagy may play an important role in cancer therapy. Several studies demonstrated that autophagy inhibition enhances apoptotic cell death. Therefore, autophagy inhibition might be a promising therapeutic method against OSCC. Our results showed that fisetin induced apoptotic cell death in human tongue squamous cell line Ca9-22 could be enhanced by inhibition of autophagy. Thus, autophagy process in fisetin treated OSCC might presumed to play a role of pro-survival. The combination of fisetin and an effective autophagy inhibitor could be a potentially adjuvant and useful treatment for oral cancer. |
| Databáze: | OpenAIRE |
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