Recombinant Human Follicle-Stimulating Hormone Alfa Dose Adjustment in US Clinical Practice: An Observational, Retrospective Analysis of a Real-World Electronic Medical Records Database
| Autor: | Mary C. Mahony, Brooke Hayward, Gilbert L. Mottla, Kevin S. Richter, Stephanie Beall, G. David Ball, Thomas D’Hooghe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
ASSISTED REPRODUCTION Databases Factual Reproductive Techniques Assisted Endocrinology Diabetes and Metabolism ANTI-MULLERIAN HORMONE dose adjustments WOMEN STARTING IVF/ICSI Diseases of the endocrine glands. Clinical endocrinology Body Mass Index Endocrinology & Metabolism Endocrinology Ovulation Induction FSH Humans r-hFSH- alfa Practice Patterns Physicians' Original Research Retrospective Studies HIGHLY PURIFIED HMG Science & Technology assisted reproductive technologies Age Factors LIVE BIRTH RC648-665 Recombinant Proteins United States ovarian stimulation INDIVIDUALIZATION Female Follicle Stimulating Hormone Human TRIAL infertility IN-VITRO FERTILIZATION Life Sciences & Biomedicine OVARIAN HYPERSTIMULATION SYNDROME |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| Popis: | PurposeTo determine the pattern of dose adjustment of recombinant human follicle-stimulating hormone alfa (r-hFSH-alfa) during ovarian stimulation (OS) for assisted reproductive technology (ART) in a real-world setting.MethodsThis was an observational, retrospective analysis of data from an electronic de-identified medical records database including 39 clinics in the USA. Women undergoing OS for ART (initiated 2009–2016) with r-hFSH-alfa (Gonal-f® or Gonal-f RFF Redi-ject®) were included. Assessed outcomes were patients’ baseline characteristics and dosing characteristics/cycle.ResultsOf 33,962 ART cycles, 13,823 (40.7%) underwent dose adjustments: 23.4% with ≥1 dose increase, 25.4% with ≥1 dose decrease, and 8.1% with ≥1 increase and ≥1 decrease. Patients who received dose adjustments were younger (mean [SD] age 34.8 [4.58] years versus 35.9 [4.60] years, p2 versus 25.5 [5.45] kg/m2, pConclusionsDose adjustment during OS is common in clinical practice in the USA and occurred more often in younger versus older patients, those with a high versus non-normal ovarian reserve or those with ovulation disorders/polycystic ovary syndrome versus other primary diagnoses of infertility. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|