Near-Infrared Chemical Imaging Slope as a New Method to Study Tablet Compaction and Tablet Relaxation
| Autor: | Jorge Ropero, Rodolfo J. Romañach, Boris Johnson-Restrepo, Yleana Colon |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Chemical imaging
Materials science Chemical Phenomena Spectrophotometry Infrared Calibration curve Compaction Analytical chemistry Lactose 030226 pharmacology & pharmacy 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lubrication Spectral slope Pressure Calibration Technology Pharmaceutical Magnesium stearate Instrumentation Spectroscopy 010401 analytical chemistry Compression (physics) 0104 chemical sciences chemistry Relaxation (physics) Stearic Acids Tablets |
| Zdroj: | Applied Spectroscopy. 65:459-465 |
| ISSN: | 0003-7028 |
| Popis: | Near-infrared chemical imaging (NIR-CI) spectra of lactose monohydrate tablets were acquired and the spectral slope from each pixel in the data hypercube was used to assess tablet compaction and relaxation. Tablets were prepared at compaction pressures of 100, 300, and 500 MPa using un-lubricated and magnesium stearate lubricated lactose monohydrate. Results show that NIR slope distribution is a function of applied compaction forces and magnesium stearate lubrication. The distribution of NIR slope values was studied using histograms and statistical parameters. The mean slope value yields a linear calibration curve that predicts tablet compaction pressure as a function of spectral slope. The NIR-CI slope measurements were also used to study tablet relaxation, which occurs as tablets release some of the stored energy from compression. The NIR-CI slope method provides a qualitative description of the relaxation process and provides quantitative information describing relaxation through time. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|