Cutting edge: histamine inhibits IFN-alpha release from plasmacytoid dendritic cells
| Autor: | Dennis M. Klinman, Alessandra Mazzoni, Margaret N. Kennedy, David M. Segal, Gregory E. D. Mullen, Cynthia A. Leifer |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
CpG Oligodeoxynucleotide
medicine.medical_treatment T cell Immunology Plasma Cells Biology Vaccines Attenuated Viral infection Ifn alpha chemistry.chemical_compound Th2 Cells Histamine H2 receptor medicine Immunology and Allergy Humans Receptors Histamine H2 Receptor Cells Cultured Tumor Necrosis Factor-alpha Interferon-alpha Dendritic Cells Th1 Cells Interleukin-12 Interleukin-10 Cytokine medicine.anatomical_structure chemistry Oligodeoxyribonucleotides Influenza A virus Influenza Vaccines Histamine |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 170(5) |
| ISSN: | 0022-1767 |
| Popis: | Plasmacytoid dendritic cells (DC) are professional APC and a major source of type I IFN following viral infection. We previously showed that histamine alters the cytokine profiles of maturing monocyte-derived DC resulting in a change from Th1 to Th2 in their T cell polarizing function. In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-α and TNF-α and a moderate switch in their capacity to polarize naive T cells. Our findings provide an explanation for low levels of type I IFN frequently observed in atopic individuals. |
| Databáze: | OpenAIRE |
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