14-Membered Macrocyclic Ring-Derived Toolbox: The Identification of Small Molecule Inhibitors of Angiogenesis and Early Embryo Development in Zebrafish Assay

Autor:	Gayathri Chandrasekar, Sridhar Balasubramanian, Prabhat Arya, Lakshindra Chetia, Naveen Kumar Mallurwar, Satish Srinivas Kitambi, Chinmoy Pramanik, Madhu Aeluri
Rok vydání:	2013
Předmět:	Macrocyclic Compounds Stereochemistry Angiogenesis Embryonic Development Angiogenesis Inhibitors Ring (chemistry) Biochemistry Structure-Activity Relationship Pregnancy Morphogenesis Animals Physical and Theoretical Chemistry Zebrafish Molecular Structure Neovascularization Pathologic biology Chemistry Organic Chemistry Embryogenesis Neurogenesis biology.organism_classification Small molecule Cell biology Drug Design Female
Zdroj:	Organic Letters. 15:436-439
ISSN:	1523-7052 1523-7060
Popis:	A highly practical and modular synthesis to obtain a diverse 14-membered ring-based macrocyclic toolbox is achieved. These compounds were further tested in zebrafish assays related to early embryonic development, angiogenesis, and neurogenesis, respectively. 1.4c was identified as an antiangiogenesis agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a4f4480a240ec0f64afb25a471ea48 https://doi.org/10.1021/ol3032126 Zobrazit plný text záznamu