SARS-CoV-2 infection and liver involvement

Autor: Mingjia Luo, Maria Pilar Ballester, Ugo Soffientini, Rajiv Jalan, Gautam Mehta
Rok vydání: 2022
Předmět:
Zdroj: Hepatology International. 16:755-774
ISSN: 1936-0541
1936-0533
Popis: The COVID-19 pandemic is the largest public health challenge in living memory. Patients with underlying liver disease have been disproportionately affected, experiencing high morbidity and mortality. In addition, elevated liver enzymes appear to be a risk factor for disease progression, even in the absence of underlying liver disease. Nevertheless, the mechanism of liver injury in SARS-CoV-2 infection remains largely unknown. This review aims to provide an overview of the mechanisms by which SARS-CoV-2 induces liver injury, and the impact of COVID-19 on cirrhosis, alcohol-related liver disease, autoimmune liver disease, non-alcoholic fatty liver disease, hepatitis B and C virus infection, liver-transplant recipients and patients with hepatocellular carcinoma. Finally, emerging data on vaccination in liver diseases is discussed, to help inform public health policy.
Databáze: OpenAIRE
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