Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6
| Autor: | Ramon M. Pujol, Anne M. Bowcock, Trilokraj Tejasvi, Philip E. Stuart, Annie Poon, Judith G.M. Bergboer, Henry W. Lim, Agnieszka Zawirska, John A.L. Armour, Geòrgia Escaramís, Francesca Capon, Xuejun Zhang, Rajan P. Nair, Anthony W. Ryan, James T. Elder, Yong Cui, John J. Voorhees, Jonathan Barker, Gang Chen, Liangdan Sun, Xavier Estivill, André Reis, Emiliano Giardina, Kati Kainu, Akira Oka, Richard C. Trembath, Ulrike Hüffmeier, Namid Munkhtuvshin, Judith Fischer, A. David Burden, Rafael de Cid, Xianyong Yin, Eva Riveira-Muñoz, Joost Schalkwijk, Tomotaka Mabuchi, Patrick L.J.M. Zeeuwen, Akira Ozawa, Heiko Traupe, Su Min He, Batmunkh Munkhbat, Hidetoshi Inoko, Giuseppe Novelli, Wilson Liao, Catherine Lee, Brian P. Kirby, Pui-Yan Kwok, Juha Kere |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Adolescent Locus (genetics) Genome-wide association study Dermatology HLA-C Antigens Biology Biochemistry Polymorphism Single Nucleotide White People 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Asian People Gene Frequency Cornified Envelope Proline-Rich Proteins Risk Factors Psoriasis medicine Humans Genetic Predisposition to Disease Young adult Molecular Biology Allele frequency Gene 030304 developmental biology Genetics 0303 health sciences Pathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1] Epistasis Genetic Cell Biology medicine.disease 3. Good health Settore MED/03 - Genetica Medica Meta-analysis Immunology Epistasis Female Gene Deletion |
| Zdroj: | Journal of Investigative Dermatology, 131, 5, pp. 1105-9 Journal of Investigative Dermatology, 131, 1105-9 |
| ISSN: | 1523-1747 0022-202X |
| Popis: | Contains fulltext : 96094.pdf (Publisher’s version ) (Closed access) A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis. |
| Databáze: | OpenAIRE |
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