Circadian Rhythms of Epinephrine and Norepinephrine in Man*
| Autor: | Christopher Linsell, Paul E. Mullen, R. C. Causon, M. J. Brown, Stafford L. Lightman |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
medicine.medical_specialty Epinephrine Endocrinology Diabetes and Metabolism Posture Clinical Biochemistry Direct response Circadian clock Biochemistry Eating Norepinephrine Endocrinology Rhythm Internal medicine medicine Humans Trough Concentration Circadian rhythm Blood Specimen Collection Chemistry Biochemistry (medical) Diurnal rhythms Circadian Rhythm Plasma epinephrine Sleep medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 60:1210-1215 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-60-6-1210 |
| Popis: | The diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men. Sleep, posture, illumination, and food intake were monitored. Plasma epinephrine demonstrated a statistically significant diurnal rhythm, with a mean amplitude of 14 +/- 1.6 (+/- SE) pg/ml superimposed on a mean level of 43 +/- 5.3 pg/ml. The trough occurred at 03.20 h +/- 35 min. Plasma norepinephrine had a significant diurnal rhythm, with a mean amplitude of 111 +/- 19 pg/ml superimposed on a mean level of 413 +/- 25 pg/ml, with the trough occurring at 02.20 h +/- 30 min. There was a significant correlation between the two rhythms at zero phase shift, with a pooled value for the group of r = 0.49. Epinephrine levels had no direct relationship to sleep or posture, whereas norepinephrine levels were significantly higher with upright posture and higher when the men were awake than when asleep. Our results indicate that circadian variations in the sympathetic-adrenal medullary system are not explained by a single controlling influence and that the norepinephrine rhythm can be accounted for as a direct response to changes in posture and sleep, whereas the epinephrine rhythm is probably controlled by a circadian oscillator. |
| Databáze: | OpenAIRE |
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