Structural insight into the catalytic mechanism of a cis-epoxysuccinate hydrolase producing enantiomerically pure d (−)-tartaric acid
| Autor: | Sheng Dong, Yingang Feng, Gu-Zhen Cui, Xi Liu, Xinquan Wang, Qiu Cui |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chemistry Stereochemistry Zinc ion Mutagenesis Metals and Alloys Substrate (chemistry) General Chemistry Crystal structure Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Hydrolase Materials Chemistry Ceramics and Composites Tartaric acid Stereoselectivity |
| Zdroj: | Chemical Communications. 54:8482-8485 |
| ISSN: | 1364-548X 1359-7345 |
| DOI: | 10.1039/c8cc04398a |
| Popis: | Crystal structure determination and mutagenesis analysis of a cis-epoxysuccinate hydrolase which produces enantiomerically pure d(-)-tartaric acids revealed a zinc ion and essential residues in the stereoselective mechanism for the catalytic reaction of the small mirror symmetric substrate. |
| Databáze: | OpenAIRE |
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