Findings of multiple HPV genotypes in cervical carcinoma are associated with poor cancer-specific survival in a Swedish cohort of cervical cancer primarily treated with radiotherapy
| Autor: | Mats G. Karlsson, Malin Kaliff, Gabriella Lillsunde-Larsson, Louise Bohr Mordhorst, Bengt Sorbe, Gisela Helenius |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Hpv genotypes HPV medicine.medical_specialty cervical cancer medicine.medical_treatment Disease survival Cancer specific survival Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Survival rate Cervical cancer recurrences business.industry virus diseases medicine.disease female genital diseases and pregnancy complications Radiation therapy 030104 developmental biology 030220 oncology & carcinogenesis Cohort business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.24666 |
| Popis: | Cervical cancer (CC) is one of the most common cancers in women and virtually all cases of CC are a result of a persistent infection of human papillomavirus (HPV). For disease detected in early stages there is curing treatment but when diagnosed late with recurring disease and metastasis there are limited possibilities. Here we evaluate HPV impact on treatment resistance and metastatic disease progression. Prevalence and distribution of HPV genotypes and HPV16 variants in a Swedish CC patient cohort (n=209) was evaluated, as well as HPV influence on patient prognosis. Tumor samples suitable for analysis (n=204) were genotyped using two different real-time PCR methods. HPV16 variant analysis was made using pyrosequencing. Results showed that HPV prevalence in the total series was 93%. Of the HPV-positive samples, 13% contained multiple infections, typically with two high-risk HPV together. Primary cure rate for the complete series was 95%. Recurrence rate of the complete series was 28% and distant recurrences were most frequent (20%). Patients with tumors containing multiple HPV-strains and particularly HPV genotypes belonging to the alpha 7 and 9 species together had a significantly higher rate of distant tumor recurrences and worse cancer-specific survival rate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|