Surgical Decision Making in the BRCA-Positive Population: Institutional Experience and Comparison with Recent Literature
| Autor: | Karinn Marie Chambers, Richard L. White, Teresa S. Flippo-Morton, Danielle Boselli, Kendall Walsh, Brook White, Lisa Amacker-North, Terry Sarantou |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Ovariectomy medicine.medical_treatment Decision Making Population Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease In patient Genetic Testing 030212 general & internal medicine education Mastectomy Retrospective Studies Genetic testing BRCA2 Protein High rate education.field_of_study medicine.diagnostic_test BRCA1 Protein business.industry fungi Age Factors Cancer Retrospective cohort study Middle Aged medicine.disease Surgery Elective Surgical Procedures 030220 oncology & carcinogenesis Mutation Female business |
| Zdroj: | The Breast Journal. 22:35-44 |
| ISSN: | 1075-122X |
| Popis: | A retrospective study was performed to document the uptake and extent of surgical intervention in patients with a known mutation in the BRCA1/2 genes and associated outcomes. Data were collected retrospectively on BRCA-positive patients with and without cancer at the time of genetic testing. Our findings were compared to those published in the current literature. Of patients with cancer at testing, 61% chose bilateral mastectomies. Of patients without cancer, 54% chose risk-reducing surgery (RRS) including risk-reducing mastectomy (RRM), risk-reducing salpingo-oophorectomy (RRSO), or both. Time to surgery was significantly shorter to RRSO than to RRM. The literature suggests and our data support that acceptance of RRM in the BRCA-positive population has gradually increased over time. Consistently high rates of RRSO uptake and short intervals from time-of-testing to RRSO demonstrate that RRSO is still more acceptable to this population than RRM. |
| Databáze: | OpenAIRE |
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