Suppressed Soft Tissue Uptake of Ga-67 After Blood Transfusion and Chemotherapy
| Autor: | Yvonne Y. Ho, Lester C. H. Leong |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Pathology medicine.medical_specialty Blood transfusion Drug-Related Side Effects and Adverse Reactions Urinary system medicine.medical_treatment Bone Neoplasms Gallium Hyperemia Diagnosis Differential Humans Medicine Radiology Nuclear Medicine and imaging Citrates Diagnostic Errors Child Radionuclide Imaging chemistry.chemical_classification Chemotherapy medicine.diagnostic_test business.industry Transfusion Reaction Soft tissue Magnetic resonance imaging General Medicine chemistry Connective Tissue Transferrin Hereditary hemochromatosis Erythropoiesis Radiopharmaceuticals Artifacts business |
| Zdroj: | Clinical Nuclear Medicine. 30:128-130 |
| ISSN: | 0363-9762 |
| Popis: | We report 2 cases of diffusely increased gallium-67 (Ga-67) skeletal uptake with suppressed soft tissue uptake and highlight the importance of a detailed clinical history, because this affects scan interpretation. Suppressed soft tissue uptake of Ga-67 occurs in hyperferremia. Iron has a high affinity for transferrin, and Ga-67 is unable to displace iron-bound transferrin. This leads to suppressed soft tissue uptake and relatively higher Ga-67 bone activity with increased urinary activity. Causes of hyperferremia include red cell transfusion, chemotherapy, and hereditary hemochromatosis. Chemotherapy increases blood iron levels by suppressing erythropoiesis. Other causes include recent radiotherapy and gadolinium for magnetic resonance imaging (MRI). |
| Databáze: | OpenAIRE |
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