Supplementary Figure 3 from Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors
| Autor: | George Coukos, Gordon J. Freeman, Karen M. Kaluza, Jaikumar Duraiswamy |
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| Rok vydání: | 2023 |
| DOI: | 10.1158/0008-5472.22395071.v1 |
| Popis: | Supplementary Figure 3 - PDF file 26K, in vivo depletion of total CD8+ and CD4+ T cells totally abolished CT26 tumor regression. Survival of mice inoculated with 0.5 x 106 CT26 tumor cells and injected i.p. with �CD4 (GK1.5, 500 �g) or �CD8 antibodies (19/178, 500 �g) day -1 and 0 (resulting in >90% of CD4+ or CD8+ T-cell depletion, respectively). Tumor size of >200mm3 was defined as lack of survival. Each curve is representative of 3 independent experiments of 12 mice per group |
| Databáze: | OpenAIRE |
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