Fracture Risk Assessment in Atypical Parkinsonian Syndromes
| Autor: | Jigisha Amin, Veronica Lyell, Celia L Gregson, Christopher Kobylecki, Emily J. Henderson, Hannah Glasse |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty FRAX Parkinson's disease fracture risk Osteoporosis Population multiple system atrophy Disease 030105 genetics & heredity BTC (Bristol Trials Centre) Progressive supranuclear palsy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine education Research Articles education.field_of_study business.industry progressive supranuclear palsy medicine.disease osteoporosis Neurology Ageing and Movement Research Group Cohort Neurology (clinical) business Body mass index 030217 neurology & neurosurgery Research Article |
| Zdroj: | Kobylecki, C, Glasse, H, Amin, J, Gregson, C L, Lyell, V R & Henderson, E J 2021, ' Fracture risk assessment in atypical parkinsonian syndromes ', Movement Disorders Clinical Practice, vol. 8, no. 3, pp. 385-389 . https://doi.org/10.1002/mdc3.13146 Kobylecki, C, Glasse, H, Amin, J, Gregson, C L, Lyell, V & Henderson, E J 2021, ' Fracture Risk Assessment in Atypical Parkinsonian Syndromes ', Movement Disorders Clinical Practice . https://doi.org/10.1002/mdc3.13146 Movement Disorders Clinical Practice |
| ISSN: | 2330-1619 |
| DOI: | 10.1002/mdc3.13146 |
| Popis: | BackgroundBone health and fracture risk reduction are increasingly recognized as important issues in Parkinson’s disease (PD). However, the evidence for fracture risk management in atypical parkinsonism (AP) is less clear. Guidance on management of bone health in PD has recently been published. ObjectivesTo evaluate the outcome of fracture risk assessment in a cohort of patients with AP, compared to a population with idiopathic PD.MethodsWe did a cross-sectional study of patients with PD or AP who had fracture risk assessed at two tertiary movement disorder centres. Data on fracture risk as assessed using QFracture and FRAX were collected. To assess for the effect of age on fracture risk we compared the risks of PD and AP patients aged ≤70 and >70 years.ResultsWe assessed 71 patients with AP and 267 with PD. Age, sex and body mass index were similar between groups; patients with AP were more likely to have fallen in the previous year. Major osteoporotic fracture risk was greater in patients with AP aged ≤70 compared to PD; no differences between groups were seen in those aged >70 years. 76% of those with AP, and 63% with PD, had an estimated fracture risk indicating bone-sparing treatment, but only 33% of patients with AP were receiving this where it was indicated.ConclusionThere is scope for considerable improvement in fracture risk assessment and treatment in atypical parkinsonism, taking into account the worse prognosis of this patient group. |
| Databáze: | OpenAIRE |
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