| Autor: |
Marco Böhler, Eline H. van den Berg, Maria C.T. Almanza, Margery A. Connelly, Stephan J.L. Bakker, Vincent E. de Meijer, Robin P.F. Dullaart, Hans Blokzijl, E. Hak, B.G. Hepkema, F. Klont, T.J. Knobbe, D. Kremer, H.G.D. Leuvenink, W.S. Lexmond, H.G.M. Niesters, L.J. van Pelt, R.A. Pol, R.J. Porte, A.V. Ranchor, J.S.F. Sanders, M.J. Siebelink, R.J.H.J.A. Slart, J.C. Swarte, D.J. Touw, M.C. van den Heuvel, C. van Leer-Buter, M. van Londen, E.A.M. Verschuuren, M.J. Vos, R.K. Weersma |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Groningen Research Institute of Pharmacy, University of Groningen, PharmacoTherapy, -Epidemiology and -Economics, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Microbes in Health and Disease (MHD), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Health Psychology Research (HPR), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), Pharmaceutical Analysis, Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Groningen Research Institute for Asthma and COPD (GRIAC), Medicinal Chemistry and Bioanalysis (MCB), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Center for Liver, Digestive and Metabolic Diseases (CLDM) |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical biochemistry, 102, 26-33. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: |
0009-9120 |
| Popis: |
BACKGROUND: Obesity, dyslipidemia and type 2 diabetes (T2D) contribute substantially to increased cardiovascular morbidity and mortality in patients after orthotopic liver transplantation (OLTx). Elevated plasma branched chain amino acids (BCAA) are linked to metabolic disturbances and cardiovascular disease (CVD) risk profiles in several non-OLTx populations.METHODS: Cross-sectional analysis of liver transplant recipients from TransplantLines, a single-center biobank and cohort study. BCAA plasma levels were measured by means of nuclear-magnetic resonance spectroscopy. CVD and cardiometabolic factors were collected by using data from electronic patient records. Associations were determined between BCAA plasma levels and T2D, Metabolic Syndrome (MetS), CVD as well as mTOR inhibition in liver transplant recipients.RESULTS: 336 Patients were divided into sex-stratified tertiles of total BCAA. MetS (PCONCLUSION: Elevated BCAA plasma levels are associated with T2D, MetS and use of Sirolimus in liver transplant recipients. BCAA plasma levels may represent a valuable biomarker for cardiometabolic complications after OLTx. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect