| Autor: |
Walker S. Jackson, Dan Ehninger, Lena C. Schmid, Julia Steffen, Jens Wagner, Susanne Schoch, Stefanie Poll, Martin Fuhrmann, Boris Schmidt |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3151990 |
| Popis: |
SummaryLearning and memory processes depend on the hippocampus and are impaired in Alzheimer’s disease (AD). Active neuronal ensembles form an engram by encoding information during learning. Their reactivation is required for memory recall. However, it remains unresolved whether the engram in CA1 principal neurons is impaired under AD-like conditions. We used two-photon in vivo imaging to visualize the expression of the immediate early gene c-fos within CA1 neurons during contextual fear conditioning and retrieval. Surprisingly, we identified engrams in wild-type mice and in the mouse model of AD indicating intact memory formation. However, under AD-like conditions engrams were superimposed by a high number of newly recruited fosGFP+ neurons during memory recall. This superimposition resembled the network configuration of wild-type mice exposed to a novel context. Artificial superimposition of the memory trace during recall in wild-type mice was sufficient to induce memory impairment. Thus, we propose superimposition of the CA1 memory trace as a mechanism for memory impairment in a mouse model of AD.HighlightsDecreased fosGFP expression in direct vicinity to amyloid-β plaquesIntact engram in CA1 of APP/PS1 miceImpurity of the retrieval network in CA1 is sufficient to impair memory recallPoll et al. present a novel mechanism for memory impairment in a mouse model of AD. The potential memory trace was found intact in the CA1 region of the hippocampus. However, excessive neuronal activity during retrieval, was superimposing the memory trace in a mouse model of AD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
