Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity

Autor: In-Sung Chung, Seung Soon Im, Kwang-Hyeon Liu, Ho Chan Cho, Jong Cheol Shon, Hyeon Young Park, Dae-Kyu Song
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Physiology
Type 2 diabetes
Biochemistry
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Risk Factors
Blood plasma
Medicine and Health Sciences
Macromolecular Structure Analysis
Diabetes diagnosis and management
Abdominal obesity
Multidisciplinary
Lipid Analysis
Incidence
Middle Aged
Lipids
Body Fluids
Sphingomyelins
Blood
Physiological Parameters
Adipose Tissue
Obesity
Abdominal
Cholesteryl ester
Medicine
medicine.symptom
Anatomy
Sphingomyelin
Research Article
Adult
medicine.medical_specialty
HbA1c
Endocrine Disorders
Science
030209 endocrinology & metabolism
Blood Plasma
Prediabetic State
03 medical and health sciences
Internal medicine
Diabetes mellitus
Republic of Korea
medicine
Diabetes Mellitus
Humans
Obesity
Hemoglobin
Molecular Biology
business.industry
Body Weight
Biology and Life Sciences
Proteins
medicine.disease
Diagnostic medicine
030104 developmental biology
Biological Tissue
chemistry
Metabolic Disorders
Metabolic syndrome
business
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0213285 (2019)
ISSN: 1932-6203
Popis: Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p < 0.0001), ceramide (r = 0.489, p < 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p < 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome.
Databáze: OpenAIRE
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