Plasma sphingomyelins increase in pre-diabetic Korean men with abdominal obesity
Autor: | In-Sung Chung, Seung Soon Im, Kwang-Hyeon Liu, Ho Chan Cho, Jong Cheol Shon, Hyeon Young Park, Dae-Kyu Song |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Male Physiology Type 2 diabetes Biochemistry Body Mass Index chemistry.chemical_compound 0302 clinical medicine Endocrinology Risk Factors Blood plasma Medicine and Health Sciences Macromolecular Structure Analysis Diabetes diagnosis and management Abdominal obesity Multidisciplinary Lipid Analysis Incidence Middle Aged Lipids Body Fluids Sphingomyelins Blood Physiological Parameters Adipose Tissue Obesity Abdominal Cholesteryl ester Medicine medicine.symptom Anatomy Sphingomyelin Research Article Adult medicine.medical_specialty HbA1c Endocrine Disorders Science 030209 endocrinology & metabolism Blood Plasma Prediabetic State 03 medical and health sciences Internal medicine Diabetes mellitus Republic of Korea medicine Diabetes Mellitus Humans Obesity Hemoglobin Molecular Biology business.industry Body Weight Biology and Life Sciences Proteins medicine.disease Diagnostic medicine 030104 developmental biology Biological Tissue chemistry Metabolic Disorders Metabolic syndrome business Biomarkers |
Zdroj: | PLoS ONE PLoS ONE, Vol 14, Iss 3, p e0213285 (2019) |
ISSN: | 1932-6203 |
Popis: | Abdominal or visceral obesity is a well-known risk factor for metabolic diseases. However, whether abdominal obesity significantly affects plasma lipid profile during the development of type 2 diabetes has not been fully elucidated. We investigated the differences in plasma lipid concentrations in 63 participants categorized into six groups (middle-aged Korean men); Normal, Pre-diabetes (pre-DM), and Diabetes mellitus (DM) with or without abdominal obesity (AO or lean). The lipidomic profiles were determined by using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Sphingomyelin (SM) levels in plasma were significantly higher in the pre-DM with AO than in pre-DM with lean (p = 0.021). SM concentrations correlated positively with waist-to-hip ratio (WHR) (r = 0.256, p = 0.044), cholesteryl ester (CE) (r = 0.483, p < 0.0001), ceramide (r = 0.489, p < 0.0001) and plasmanyl phosphatidylcholine (PC) (r = 0.446, p < 0.0001). The present study found that pre-diabetic patients with AO were characterized by increased plasma concentrations of SM. Plasma SM levels in individuals with AO may be an early prognostic biomarker to better predict the progression toward type 2 diabetes and metabolic syndrome. |
Databáze: | OpenAIRE |
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