Polycatecholamine and gentamicin as modifiers for antibacterial and blood-biocompatible polyester vascular prostheses

Autor:	Anna Michalicha, Albert Espona-Noguera, Cristina Canal, Barbara Budzyńska, Mateusz Pięt, Stanisław Przywara, Jarosław Pawelec, Anna Belcarz
Rok vydání:	2022
Předmět:	Biomaterials Levodopa Prosthesis-Related Infections Coated Materials Biocompatible Polyesters Biomedical Engineering Animals Endothelial Cells Humans Bioengineering Gentamicins Anti-Bacterial Agents Blood Vessel Prosthesis
Zdroj:	Biomaterials Advances
ISSN:	0928-4931
DOI:	10.1016/j.msec.2022.112645
Popis:	Polyester (PET) prostheses are commonly used in reconstructive vascular surgery. The most serious complication after implantation is early or late infection of the graft. Therefore, there is high demand to protect prosthesis against bacterial adhesion and biofilm development. For this reason, in this work PET prostheses were first coated by highly adhesive polycatecholamine layer. The grafts were then coupled with gentamicin and studied in relation to morphological and structural properties, biological safety (contact with blood, reaction of vascular endothelial cells (HUVEC), Danio rerio fish), drug release and antibacterial activity. Among two tested catecholamine monomers, L-DOPA was found to be more effective precursor in this process than dopamine. For L-DOPA, assistance of Cu
Databáze:	OpenAIRE
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