In Situ Nanotransformable Hydrogel for Chemo-Photothermal Therapy of Localized Tumors and Targeted Therapy of Highly Metastatic Tumors
| Autor: | Veeresh B, Aravind Kumar Rengan, Syed Baseeruddin Alvi, Rajalakshmi P S, Anil Jogdand, Nazia Begum |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lung Neoplasms
Materials science Palliative care Photothermal Therapy Surface Properties Injections Subcutaneous medicine.medical_treatment Melanoma Experimental Biocompatible Materials Cell Line Metastasis Targeted therapy Mice In vivo medicine Animals General Materials Science Particle Size Mice Inbred BALB C Chemotherapy Antibiotics Antineoplastic Melanoma technology industry and agriculture Hydrogels Neoplasms Experimental Photothermal therapy medicine.disease Mice Inbred C57BL Doxorubicin Liposomes Self-healing hydrogels Cancer research Nanoparticles Female Gold |
| Zdroj: | ACS Applied Materials & Interfaces. 13:55862-55878 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.1c17054 |
| Popis: | Metastasis is one of the predisposing factors for cancer-related mortalities worldwide. Patients with advanced cancers (stage IV) receive palliative care with minimal possibility of achieving complete remission. Antibody-based therapeutic modalities are capable of targeting tumors that are confined to a particular location but are ineffective in targeting distant secondary tumors. In the current study, we have developed a smart nano-transforming hydrogel (NTG) that transforms in situ to polymeric nanoparticles (PA NPs) of 100-150 nm when injected subcutaneously. These nanoparticles targeted the primary and secondary metastatic tumors for up to ∼5 and ∼3 days, respectively. The in situ-formed PA NPs also demonstrated a pH-responsive drug release resulting in about ∼80% release within 100 h at 5.8 pH. When tested in vivo, substantial inhibition of lung metastases was observed compared to chemotherapy, thus demonstrating the efficiency of nanotransforming hydrogels in targeting and inhibiting primary and secondary metastatic tumors. |
| Databáze: | OpenAIRE |
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