Pharmacokinetic Evaluation of a Single Intramuscular High Dose versus an Oral Long-Term Supplementation of Cholecalciferol

Autor: Gennadiy Drozdenko, Margitta Worm, Alexander Krannich, Sabine Dölle, Guido Heine, K. Wylon
Rok vydání: 2015
Předmět:
Male
lcsh:Medicine
Administration
Oral
Organic chemistry
600 Technik
Medizin
angewandte Wissenschaften::610 Medizin und Gesundheit
Placebo group
Cohort Studies
chemistry.chemical_compound
0302 clinical medicine
Elderly
Oral administration
030212 general & internal medicine
Vitamin D
lcsh:Science
Routes of Administration
Cholecalciferol
Multidisciplinary
Vitamins
Physical sciences
Chemistry
Nutritional deficiencies
Micronutrient Deficiencies
Female
Intramuscular injection
Research Article
Adult
medicine.medical_specialty
030209 endocrinology & metabolism
Injections
Intramuscular
vitamin D deficiency
03 medical and health sciences
Chemical compounds
Pharmacokinetics
Internal medicine
Organic compounds
medicine
Vitamin D and neurology
Humans
Intramuscular Injections
Nutrition
Medicine and health sciences
Pharmacology
Vitamin D deficiency
Biology and life sciences
business.industry
lcsh:R
Vitamin D intake
medicine.disease
Endocrinology
chemistry
Geriatrics
Age Groups
People and Places
lcsh:Q
Population Groupings
business
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0169620 (2017)
ISSN: 1932-6203
Popis: Background and Objectives Vitamin D deficiency is frequent during the winter and occurs throughout the year in the elderly or patients suffering from autoimmune diseases. The objective of this study was to evaluate the pharmacokinetic properties of oral supplementation versus a single intramuscular injection of cholecalciferol in healthy individuals. Research design and methods Up to 8,000 I.U. oral cholecalciferol was administered daily for 84 days in a 4 week dose-escalation setting to vitamin D deficient individuals. In another cohort, a single intramuscular injection of 100,000 I.U. cholecalciferol was given. In both cohorts, individuals without vitamin D intake served as the comparison group. 25-hydroxyvitamin D (25(OH)D) concentrations were measured in all individuals at defined time points throughout the studies. Results The mean 25(OH)D serum concentration increased significantly after oral cholecalciferol intake compared to the control group (day 28: 83.4 nmol/l and 42.5 nmol/l; day 56: 127.4 nmol/l and 37.3 nmol/l; day 84: 159.7 nmol/l and 30.0 nmol/l). In individuals receiving 100,000 I.U. cholecalciferol intramuscular, the mean 25(OH)D serum concentration peaked after 4 weeks measuring 70.9 nmol/l compared to 32.7 nmol/l in the placebo group (p = 0.002). The increase of 25(OH)D serum concentrations after 28 days was comparable between both routes of administration (p = 0.264). Conclusions Oral and intramuscular cholecalciferol supplementation effectively increased serum 25(OH)D concentrations.
Databáze: OpenAIRE
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