Modulation of the corticospinal control of ventilation by changes in reflex respiratory drive
| Autor: | Abraham Guz, Lewis Adams, C. A. Roberts, Douglas R. Corfield, Kevin Murphy |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Hypercapnia Physical medicine and rehabilitation Physiology (medical) Reflex medicine Humans Compensatory tracking task Respiratory system Trained subjects Cerebral Cortex business.industry Carbon Dioxide Respiratory Function Tests Oxygen Spinal Cord Spirometry Control of respiration Anesthesia Respiratory Mechanics Female Respiratory control business Psychomotor Performance |
| Zdroj: | Journal of Applied Physiology. 87:1923-1930 |
| ISSN: | 1522-1601 8750-7587 |
| Popis: | We have determined whether changes in [Formula: see text]above and below eucapnia modulate the precision of the voluntary control of breathing. Twelve trained subjects performed a compensatory tracking task in which they had to maintain the position of a cursor (perturbed by a variable triangular forcing function) on a fixed target by breathing in and out of a spirometer (ventilatory tracking; at 10 l/min). Before each task, subjects hyperventilated for 5 min, and the end-tidal [Formula: see text]([Formula: see text]) was controlled; tracking was then performed separately at hypocapnia, eucapnia, and hypercapnia ([Formula: see text] ∼25, 37, and 43 Torr, respectively). Ventilatory tracking error was unchanged during hypocapnia ( P > 0.05) but was significantly worse during hypercapnia ( P < 0.003), compared with eucapnia; arm tracking error, performed as a control, was not significantly affected by[Formula: see text]( P > 0.05). In conclusion, ventilatory tracking performance is unaffected by the eucapnic[Formula: see text]. From this, we suggest that resting breathing in awake humans may be independent of chemical drives and of the prevailing [Formula: see text]. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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