Amphetamine and other pharmacological agents in human and animal studies of recovery from stroke
| Autor: | Patricia S. Smith, Mark D. Johnson, J. Mehta, Delaina Walker-Batson |
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| Rok vydání: | 2014 |
| Předmět: |
03 medical and health sciences
0302 clinical medicine Pharmacotherapy Donepezil Hydrochloride Aphasia medicine Animals Humans Amphetamine Stroke Biological Psychiatry Pharmacology Recovery of Function medicine.disease Neuromodulation (medicine) 030227 psychiatry Clinical trial Neuroprotective Agents Animal studies medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 64 |
| ISSN: | 1878-4216 |
| Popis: | Neuromodulation with pharmacological agents, including drugs of abuse such as amphetamine, when paired with behavioral experience, has been shown to positively modify outcomes in animal models of stroke. A number of clinical studies have tested the efficacy of a variety of drugs to enhance recovery of language deficit post-stroke. The purpose of this paper is to: (1) present pertinent animal studies supporting the use of dextro-amphetamine sulfate (AMPH) to enhance recovery after experimental lesions with emphasis on the importance of learning dependent activity for lasting recovery; (2) briefly review neuropharmacological explorations in the treatment of aphasia; (3) present a pilot study in aphasia exploring a drug combination of AMPH and donepezil hydrochloride paired with behavioral treatment to facilitate recovery; and (4) conclude with comments regarding the role of adjunctive pharmacotherapy in the rehabilitation of aphasia, particularly AMPH. |
| Databáze: | OpenAIRE |
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