Preliminary Data on Preimplantation Genetic Diagnosis for Hemoglobinopathies in Turkey

Autor:	Filiz Zeren, Mehmet Akif Çürük, Ahmet Genc
Přispěvatelé:	Çukurova Üniversitesi
Rok vydání:	2007
Předmět:	Male medicine.medical_specialty Turkey Hemoglobins Abnormal education ß-Thalassemia (thal) Clinical Biochemistry Prenatal diagnosis Preimplantation genetic diagnosis (PGD) Preimplantation genetic diagnosis Compound heterozygosity Pregnancy hemic and lymphatic diseases medicine Humans Genetics (clinical) Genetics Sickle cell trait Obstetrics business.industry Incidence (epidemiology) beta-Thalassemia Biochemistry (medical) Beta thalassemia Hematology medicine.disease humanities Sickle cell anemia Hemoglobinopathies Blastocyst Female business
Zdroj:	Hemoglobin. 31:273-277
ISSN:	1532-432X 0363-0269
DOI:	10.1080/03630260701297238
Popis:	PubMedID: 17486511 Hemoglobinopathies are the most common genetic diseases in Turkey. Sickle cell anemia is prevalent in the Çukurova region but ß-thalassemia (thal) is seen all over the country. The incidence of sickle cell trait is 10% and ß-thal trait is 3.7% in this region. The families at risk for hemoglobinopathies have come to our center for prenatal diagnosis since 1992. In 15 years, 1,593 fetuses were examined. Four hundred and ten fetuses were found to be homozygous or compound heterozygous for sickle cell anemia and ß-thal. Some mothers had affected fetuses several times. Preimplantation genetic diagnosis (PGD) is an option to avoid the termination of a pregnancy. Studies for PGD of sickle cell anemia were done at Çukurova University Hospital, Çukurova, Adana, Turkey. Copyright © Informa Healthcare. Çukurova Üniversitesi: TF2002BAP85 The authors would like to thank the following scientists from Çukurova University Hospital: Professor Dr. Kiymet Aksoy and Associate Professor Dr. Abdullah Tuli (Department of Biochemistry) for their contributions, Professor Dr. Yurdanur Kilinç (Pediatric Hematology Clinic) for the blood samples, Professor Dr. Fatma T. Ozgunen, Professor Dr. Cüneyt Evrüke and Professor Dr. Cansun Demir (Obstetrics and Gynecology Clinic) for the chorionic villus samples (CVS) and Professor Dr. Suna Solmaz and Professor Dr. Turan Çetin (IVF Unit) for the embryos. This project was supported by the Çukurova University Research Grant TF2002BAP85.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2982a1d4b2b653deccb7f1ab784073ef https://doi.org/10.1080/03630260701297238 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.