Lanostane-Type Triterpenes from the Mushroom Astraeus pteridis with Antituberculosis Activity
| Autor: | Mohamed M. Radwan, Frank R. Fronczek, James M. Trappe, Samir A. Ross, Rita Stanikunaite |
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| Rok vydání: | 2008 |
| Předmět: |
Astraeus pteridis
Stereochemistry Antitubercular Agents Pharmaceutical Science Phenylalanine Microbial Sensitivity Tests Lanostane Analytical Chemistry Terpene Mycobacterium tuberculosis Lanosterol Oregon chemistry.chemical_compound Betaine Chlorocebus aethiops Drug Discovery Animals Agaricales Vero Cells Pharmacology Mushroom Molecular Structure biology Chemistry Organic Chemistry biology.organism_classification Triterpenes Complementary and alternative medicine Molecular Medicine |
| Zdroj: | Journal of Natural Products. 71:2077-2079 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np800577p |
| Popis: | Bioassay-guided fractionation of an EtOH extract of the truffle-mimiking mushroom Astraeus pteridis led to the isolation and identification of three new (3-5) and two known (1, 2) lanostane triterpenes and phenylalanine betaine (6). The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectroscopic data, HRESIMS results, and X-ray crystallographic analysis. Compounds 5 and 1 showed moderate activity against Mycobacterium tuberculosis with MIC values of 34.0 and 58.0 microg/mL, respectively. |
| Databáze: | OpenAIRE |
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