Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department
| Autor: | Hsu Ma, Yi-Ru Jin, Jang-Hwa Lee, Shih-Meng Tsai, Sheng-Yi Chen, Li-Yu Tsai, Szu-Hsien Wu, Ing-Jun Chen, Fong-Dee Huang, Yang-Ming Tseng |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Clinical Biochemistry Alcohol abuse Alcohol medicine.disease_cause digestive system Biochemistry Gastroenterology chemistry.chemical_compound Polymorphism (computer science) Internal medicine Genetic variation Genotype medicine Humans Aged ALDH2 business.industry Biochemistry (medical) Alcohol Dehydrogenase Genetic Variation General Medicine Emergency department Aldehyde Dehydrogenase Middle Aged medicine.disease digestive system diseases chemistry Wounds and Injuries Female Emergency Service Hospital business Alcoholic Intoxication Oxidative stress |
| Zdroj: | Clinica Chimica Acta. 389:14-18 |
| ISSN: | 0009-8981 |
| DOI: | 10.1016/j.cca.2007.11.010 |
| Popis: | Background Alcohol abuse has been implicated as an important factor for accidents. We evaluated the roles of different genetic combinations of the ADH2 and ALDH2 genotypes on biomarkers in trauma patients with excessive alcohol intake at our emergency department. Methods Blood samples were obtained from 80 patients and 88 age-matched controls. The biomarkers, including AST, ALT, GGT, and MDA, were assayed. The polymerase chain reaction-restriction fragment length polymorphism method was used to determine the genetic polymorphisms of ADH2 and ALDH2. Results There were significant differences in the levels of AST, ALT, GGT, MDA, and AST/ALT ratios between the 2 groups. In addition, MDA values and AST/ALT ratios were significantly higher in the patients with normal activity of ADH2 than the patients with low activity of ADH2. Meanwhile, regarding ALDH2 genotypes, there were significantly higher ratios of AST/ALT in the patients with low activity of ALDH2. The highest AST/ALT ratios and MDA values were in the patients with ADH2 (⁎2/⁎2) and ALDH2 (⁎1/⁎2 and ⁎2/⁎2). Conclusions In conclusion, our results indicated that alcohol-induced liver damage or oxidative stress might be influenced by the genetic variation of ADH2 or ALDH2. Therefore, the combinations of different ADH2 and ALDH2 genotypes may be influential markers for susceptibility to alcohol-induced liver damage. |
| Databáze: | OpenAIRE |
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