Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Autor: van Bilsen, Jolanda H M, Sienkiewicz-Szłapka, Edyta, Lozano-Ojalvo, Daniel, Willemsen, Linette E. M., Antunes, Celia M, Molina, Elena, Smit, Joost J., Wróblewska, Barbara, Wichers, Harry J., Knol, Edward F., Ladics, Gregory S, Pieters, Raymond H. H., Denery-Papini, Sandra, Vissers, Yvonne M, Bavaro, Simona L, Larré, Colette, Verhoeckx, Kitty C M, Roggen, Erwin L, Afd Pharmacology, Sub IRAS Tox ITX (immunotoxicologie), dIRAS RA-1
Přispěvatelé: Afd Pharmacology, Sub IRAS Tox ITX (immunotoxicologie), dIRAS RA-1, The Netherlands Organisation for Applied Scientific Research (TNO), University of Warmia and Mazury, Instituto de Investigación en Ciencias de la Alimentación (CIAL), Utrecht University [Utrecht], University of Evora, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Wageningen University and Research Center (WUR), University Medical Center [Utrecht], DuPont Company, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de la Recherche Agronomique (INRA), Nestlé Research Center, Nestle Reasearch Center, Institute of Sciences of Food Production (ISPA), Consiglio Nazionale delle Ricerche (CNR), 3Rs Managing and Consulting ApS, Wageningen University and Research [Wageningen] (WUR)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Pulmonary and Respiratory Medicine
[SDV]Life Sciences [q-bio]
Population
Immunology
Context (language use)
Computational biology
Review
Sensitization
Food proteins
Allergic sensitization
03 medical and health sciences
0302 clinical medicine
Adverse outcome pathway
Food allergy
Adverse Outcome Pathway
Journal Article
Medicine
Immunology and Allergy
Mechanistic understanding
Animal testing
education
Tissue homeostasis
Food
Health & Consumer Research
VLAG
Key events
education.field_of_study
business.industry
RC581-607
medicine.disease
Key event relations
Molecular initiating event
3. Good health
Food proteins
Molecular initiating event
030104 developmental biology
medicine.anatomical_structure
Health & Consumer Research
Food
Immunologic diseases. Allergy
business
Mechanisticunderstanding
030215 immunology
Zdroj: Clinical and Translational Allergy
Clinical and Translational Allergy, 7(1). BioMed Central
Clinical and Translational Allergy 7 (2017) 1
Clinical and Translational Allergy, BioMed Central, 2017, pp.1-18. ⟨10.1186/s13601-017-0152-0⟩
Clinical and Translational Allergy, 1-18. (2017)
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Digital.CSIC. Repositorio Institucional del CSIC
instname
Clinical and Translational Allergy, 7(1)
Clinical and Translational Allergy, Vol 7, Iss 1, Pp 1-18 (2017)
ISSN: 2045-7022
DOI: 10.1186/s13601-017-0152-0⟩
Popis: [Background] The introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP).
[Main body] The proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell–cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential.
[Conclusion] The application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.
Databáze: OpenAIRE
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