In Vitro Innovation of Tendon Tissue Engineering Strategies
| Autor: | Carlo Barbera, Maria Camilla Ciardulli, Mohammad El Khatib, Valentina Russo, Devis Galesso, Nicholas R. Forsyth, Giovanna Della Porta, Nicola Maffulli, Annunziata Mauro, Maria Rita Citeroni, Miriam Di Mattia, Barbara Barboni |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Review Tendon tissue Bioinformatics Catalysis RS Tendons Inorganic Chemistry lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Tissue engineering Fibrosis tendon differentiation stem cells medicine Animals Humans Regeneration Physical and Theoretical Chemistry Molecular Biology Process (anatomy) Tendon healing lcsh:QH301-705.5 Spectroscopy Wound Healing Tissue Engineering business.industry Regeneration (biology) Organic Chemistry Cell Differentiation in vitro General Medicine medicine.disease Computer Science Applications Tendon 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 030220 oncology & carcinogenesis Tendinopathy business |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6726, p 6726 (2020) International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Popis: | Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon healing results in scar tissue formation and fibrosis with suboptimal biomechanical properties, often resulting in poor and painful mobility. The biomechanical properties of the tissue are negatively affected. Adult tendons have a limited natural healing capacity, and often respond poorly to current treatments that frequently are focused on exercise, drug delivery, and surgical procedures. Therefore, it is of great importance to identify key molecular and cellular processes involved in the progression of tendinopathies to develop effective therapeutic strategies and drive the tissue toward regeneration. To treat tendon diseases and support tendon regeneration, cell-based therapy as well as tissue engineering approaches are considered options, though none can yet be considered conclusive in their reproduction of a safe and successful long-term solution for full microarchitecture and biomechanical tissue recovery. In vitro differentiation techniques are not yet fully validated. This review aims to compare different available tendon in vitro differentiation strategies to clarify the state of art regarding the differentiation process. |
| Databáze: | OpenAIRE |
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