A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging

Autor:	Hongyue Lou, Aiyan Ji, Chunrong Qu, Hongguang Liu, Lei Jiang, Hao Chen, Zhen Cheng
Rok vydání:	2022
Předmět:	Mice Photothermal Therapy Cell Line Tumor Optical Imaging Animals Nanoparticles General Materials Science Phototherapy Theranostic Nanomedicine
Zdroj:	ACS Applied Materials & Interfaces. 14:35454-35465
ISSN:	1944-8252 1944-8244
Popis:	Near-infrared window IIb (NIR-IIb, 1500-1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, low absorption, and deep tissue penetration, and photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now, there is no report on theranostic systems based on small organic molecules combining fluorescence imaging in the NIR-IIb and PTT, highlighting the challenge and strong need for development of such agents. Herein, we report a novel small molecule NIR-IIb dye IT-TQF with a D-A-D structure, which exhibited high fluorescence intensity in the NIR-IIb window. To further translate IT-TQF into an effective theranostic agent, IT-TQF was encapsulated into DSPE-PEG
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297a32022c7c273628d4a0d0e675bd76 https://doi.org/10.1021/acsami.2c11706 Zobrazit plný text záznamu