A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging
Autor: | Hongyue Lou, Aiyan Ji, Chunrong Qu, Hongguang Liu, Lei Jiang, Hao Chen, Zhen Cheng |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | ACS Applied Materials & Interfaces. 14:35454-35465 |
ISSN: | 1944-8252 1944-8244 |
Popis: | Near-infrared window IIb (NIR-IIb, 1500-1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, low absorption, and deep tissue penetration, and photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now, there is no report on theranostic systems based on small organic molecules combining fluorescence imaging in the NIR-IIb and PTT, highlighting the challenge and strong need for development of such agents. Herein, we report a novel small molecule NIR-IIb dye IT-TQF with a D-A-D structure, which exhibited high fluorescence intensity in the NIR-IIb window. To further translate IT-TQF into an effective theranostic agent, IT-TQF was encapsulated into DSPE-PEG |
Databáze: | OpenAIRE |
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