Autophagy response in the liver of pigeon exposed to avermectin
| Autor: | Ci Liu, Shu Li, Pervez Ahmed Khoso, Xian-Song Wang, Weijia Zheng, Ming Li |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Insecticides Health Toxicology and Mutagenesis ATG5 Dynein Environmental pollution Vacuole Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation Organelle Autophagy Animals Environmental Chemistry Columbidae Avermectin Ivermectin General Medicine Pollution 030104 developmental biology Liver chemistry Biochemistry 030220 oncology & carcinogenesis |
| Zdroj: | Environmental Science and Pollution Research. 24:12767-12777 |
| ISSN: | 1614-7499 0944-1344 |
| DOI: | 10.1007/s11356-016-6209-0 |
| Popis: | Pesticide residues are an important aspect of environmental pollution. Environmental avermectin residues have produced adverse effects in organisms. Many pesticides exert their toxic effects via the mechanism of autophagy. The purpose of this study was to examine the changes in autophagy levels and in autophagy-related genes, including LC3, Beclin 1, Dynein, ATG5, TORC1, and TORC2, resulting from exposure to subchronic levels of AVM in liver tissue in the king pigeon model. We observed abundant autophagic vacuoles with extensively degraded organelles, autophagosomal vacuoles, secondary lysosomes, and double-membrane structures in the liver. The expression levels of the autophagy-related genes LC3-I, LC3-II, Beclin 1, ATG5, and Dynein were up-regulated; however, TORC1 and TORC2 expression levels were down-regulated. These changes occurred in a concentration-dependent manner after AVM exposure for 30, 60, and 90 days in pigeons. Taken together, these results suggested that AVM increased the autophagic flux and that upregulation of autophagy might be closely related to the hepatotoxicity of AVM in birds. |
| Databáze: | OpenAIRE |
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