Pitfalls in the use of chromosome aberration analysis for biological radiation dosimetry
| Autor: | Heather B. A. Sharpe |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Chromosome Aberrations
Dosimeter Colcemid business.industry General Medicine Biology Radiation Chromosome aberration Peripheral blood chemistry.chemical_compound chemistry Culture Techniques Cancer research Dosimetry Humans Radiology Nuclear Medicine and imaging Lymphocytes Nuclear medicine business Colchicine Radiometry Metaphase Mitosis |
| Zdroj: | The British journal of radiology. 42(504) |
| ISSN: | 0007-1285 |
| Popis: | The use of chromosomes as biological radiation dosimeters is a well-established and valuable technique, especially when physical methods are inadequate or not available. This technique has also been used in studies of lymphocyte kinetics (Sharpe, Dolphin, Dawson and Field, 1967; 1968). Peripheral blood lymphocytes are stimulated in culture to go into division and then arrested in mitosis with Colcemid. Radiation damage can be seen in the metaphase chromosomes and the amount of damage can be related to the dose of radiation (Bender and Gooch, 1962). |
| Databáze: | OpenAIRE |
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