Malignant Chondroid Syringoma
| Autor: | G. Rassner, Gundula Schaumburg-Lever, O. Hornstein, Gisela Metzler |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Stromal cell Adenoma biology Carcinoma Mesenchymal stem cell Adenoma Pleomorphic Vimentin Dermatology General Medicine medicine.disease Immunohistochemistry Glandular Differentiation Malignant mixed tumor Pathology and Forensic Medicine Sweat Gland Neoplasms Cytokeratin medicine.anatomical_structure Sweat gland medicine biology.protein Humans |
| Zdroj: | The American Journal of Dermatopathology. 18:83-89 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/00000372-199602000-00014 |
| Popis: | Malignant chondroid syringoma, also called malignant mixed tumor of the skin, is a rare variant of a malignant tumor derived from sweat gland cells. Histologically the tumor is composed of an epithelial and a mesenchymal component. The epithelial structures show glandular differentiation and carcinomatous features. They are embedded in a mucinous stroma with spindle mesenchymal cells and areas of chondroid differentiation. The epithelial cells express cytokeratins. The luminal epithelial cells show binding to the lectin Ulex europaeus; intraluminal cells are carcinoembryonic antigen positive. The stromal cells are cytokeratin negative and sporadically positive for vimentin. Chondroid areas are S-100 protein and vimentin positive. No labeling for actin is seen. |
| Databáze: | OpenAIRE |
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