Carcinoembryonic Antigen as a Selective Enhancer of Colorectal Cancer Metastasis
| Autor: | R. Mankarious, Peter Thomas, C. A. Toth, Dominic Fan, J. M. Jessup, Kefung Chi, R. B. Hostetter, L. B. Augustus |
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| Rok vydání: | 1990 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Poor prognosis endocrine system diseases Experimental metastasis Colorectal cancer Systemic injection Mice Nude Metastasis Mice Carcinoembryonic antigen Internal medicine Tumor Cells Cultured medicine Animals Enhancer neoplasms Cell Aggregation Mice Inbred BALB C biology business.industry Liver Neoplasms medicine.disease digestive system diseases Carcinoembryonic Antigen biology.protein Antibody Colorectal Neoplasms business Plastics Neoplasm Transplantation |
| Zdroj: | JNCI Journal of the National Cancer Institute. 82:380-385 |
| ISSN: | 1460-2105 0027-8874 |
| DOI: | 10.1093/jnci/82.5.380 |
| Popis: | Although the serum level of carcinoembryonic antigen (CEA) is directly associated with a poor prognosis in human colorectal carcinoma (CRC), its function is obscure. As a member of the immunoglobulin supergene family, CEA may be involved with intercellular recognition and binding and facilitate attachment of CRC to sites of metastasis. In an experimental metastasis model of CRC in athymic nude mice, a systemic injection of CEA enhanced experimental liver metastasis and implantation in liver by a weakly metastatic CRC. This CRC also selectively bound to CEA that was attached to plastic. Thus, CEA may function as an attachment factor for CRC. |
| Databáze: | OpenAIRE |
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