Contribution of Dietary Oxalate and Oxalate Precursors to Urinary Oxalate Excretion
| Autor: | John Knight, Joseph J. Crivelli, Tanecia Mitchell, Kyle Wood, Ross P. Holmes, Sonia Fargue, Dean G. Assimos |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Oxalobacter formigenes kidney stones 030232 urology & nephrology Calcium oxalate lcsh:TX341-641 Review Kidney Nephrolithiasis Oxalate Excretion 03 medical and health sciences chemistry.chemical_compound Kidney Calculi 0302 clinical medicine Internal medicine medicine Humans Oxalates oxalate Nutrition and Dietetics Vitamin C biology Bacteria Calcium Oxalate dietary oxalate Chemistry oxalate synthesis urolithiasis medicine.disease biology.organism_classification Ascorbic acid Diet Gastrointestinal Microbiome 030104 developmental biology Endocrinology Kidney stone disease Kidney stones lcsh:Nutrition. Foods and food supply metabolism Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 62, p 62 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Kidney stone disease is increasing in prevalence, and the most common stone composition is calcium oxalate. Dietary oxalate intake and endogenous production of oxalate are important in the pathophysiology of calcium oxalate stone disease. The impact of dietary oxalate intake on urinary oxalate excretion and kidney stone disease risk has been assessed through large cohort studies as well as smaller studies with dietary control. Net gastrointestinal oxalate absorption influences urinary oxalate excretion. Oxalate-degrading bacteria in the gut microbiome, especially Oxalobacter formigenes, may mitigate stone risk through reducing net oxalate absorption. Ascorbic acid (vitamin C) is the main dietary precursor for endogenous production of oxalate with several other compounds playing a lesser role. Renal handling of oxalate and, potentially, renal synthesis of oxalate may contribute to stone formation. In this review, we discuss dietary oxalate and precursors of oxalate, their pertinent physiology in humans, and what is known about their role in kidney stone disease. |
| Databáze: | OpenAIRE |
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