Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men

Autor: Stefanie Pagels, Markus Grube, Peter Meisel, Thomas Kocher, Gabriele Jedlitschky, Henry Völzke
Rok vydání: 2020
Předmět:
Zdroj: Clin Oral Investig
Clinical Oral Investigations
ISSN: 1436-3771
1432-6981
DOI: 10.1007/s00784-020-03594-w
Popis: Objective SLC22A4/5 single nucleotide polymorphisms (SNPs) have been reported to affect inflammatory diseases. We report the relationship of these polymorphisms with adiposity and tooth loss as elucidated in a 10-year follow-up study. Methods Participants of the Study of Health in Pomerania (SHIP, N = 4105) were genotyped for the polymorphisms c.1507C > T in SLC22A4 (rs1050152) and -207C > G in SLC22A5 (rs2631367) using allele-specific real-time PCR assays. A total of 1817 subjects, 934 female and 883 male aged 30–80 years, underwent follow-up 10 years later (SHIP-2) and were assessed for adiposity and tooth loss. Results The frequencies of the rarer SLC22A4 TT and SLC22A5 CC alleles were 16.7% and 20.3%, respectively. In women, tooth loss was associated with genotype TT vs. CC with incidence rate ratio IRR = 0.74 (95% C.I. 0.60–0.92) and CC vs. GG IRR = 0.79 (0.65–0.96) for SLC22A4 and SLC22A5 SNPs, respectively. In men, no such associations were observed. In the follow-up examination, the relationship between tooth loss and these SNPs was in parallel with measures of body shape such as BMI, body weight, waist circumference, or body fat accumulation. The association between muscle strength and body fat mass was modified by the genotypes studied. Conclusions SLC22A4 c.150C > T and SLC22A5 -207C > G polymorphisms are associated with tooth loss and markers of body shape in women but not in men. Clinical relevance Tooth loss may be related to obesity beyond inflammatory mechanisms, conceivably with a genetic background.
Databáze: OpenAIRE
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