Kir4.1 is specifically expressed and active in non‐myelinating Schwann cells

Autor: Nicole M. Procacci, Robert Louis Hastings, Aamir A. Aziz, Nina M. Christiansen, Jie Zhao, Claire DeAngeli, Normand LeBlanc, Lucia Notterpek, Gregorio Valdez, Thomas W. Gould
Rok vydání: 2022
Předmět:
Zdroj: Glia. 71:926-944
ISSN: 1098-1136
0894-1491
DOI: 10.1002/glia.24315
Popis: Non-myelinating Schwann cells (NMSC) play important roles in peripheral nervous system formation and function. However, the molecular identity of these cells remains poorly defined. We provide evidence that Kir4.1, an inward-rectifying K+ channel encoded by the KCNJ10 gene, is specifically expressed and active in NMSC. Immunostaining revealed that Kir4.1 is present in terminal/perisynaptic SCs (TPSC), synaptic glia at neuromuscular junctions (NMJ), but not in myelinating SCs (MSC) of adult mice. To further examine the expression pattern of Kir4.1, we generated BAC transgenic Kir4.1-CreER
Databáze: OpenAIRE
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