Insulin and glucagon releasing activity of coleonol (forskolin) and its effect on blood glucose level in normal and alloxan diabetic rats
| Autor: | Mohammed Mubin Khan, Anil K. Rastogi, Faiyaz Ahmad, Jalil R. Kidwai |
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| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Stimulation Fatty Acids Nonesterified In Vitro Techniques Biology Glucagon Diabetes Mellitus Experimental Islets of Langerhans chemistry.chemical_compound Endocrinology Reference Values Internal medicine Diabetes mellitus Alloxan Insulin Secretion Internal Medicine medicine Animals Insulin chemistry.chemical_classification Forskolin Glycogen Colforsin Fatty acid Rats Inbred Strains General Medicine medicine.disease Liver Glycogen Rats Kinetics Liver chemistry Glucose-6-Phosphatase |
| Zdroj: | Acta Diabetologica Latina. 28:71-77 |
| ISSN: | 1432-5233 0001-5563 |
| DOI: | 10.1007/bf02732116 |
| Popis: | Colenol, a diterpenoid isolated from the roots of Coleus forskohlii stimulates the release of insulin and glucagon from the islets both in vitro and in vivo. Colenol-stimulated release of glucagon from islets in vitro is much more pronounced as compared to that of insulin. Glucose concentration of 5.6 mM in the medium is required for the colenol stimulation of insulin release. Feeding of coleonol to alloxan diabetic rats cause 36.5% increase in blood glucose level as compared to alloxan diabetic control. Oral feeding of coleonol for 7 days to normal rats causes increase in blood glucose, serum insulin, glucagon and free fatty acid levels with corresponding increase in glucose-6-phosphatase activity and depletion of liver glycogen. Predominant stimulation of A-cells by coleonol is suggested for the above effects. |
| Databáze: | OpenAIRE |
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