Gastric neuromuscular histology in patients with refractory gastroparesis: Relationships to etiology, gastric emptying, and response to gastric electric stimulation
| Autor: | R. M. Thomas, Jason Heckert, Henry P. Parkman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Abdominal pain Gastroparesis Physiology Nausea H&E stain Electric Stimulation Therapy Gastroenterology Masson's trichrome stain 03 medical and health sciences symbols.namesake 0302 clinical medicine Internal medicine medicine Humans Gastric emptying Endocrine and Autonomic Systems business.industry medicine.disease Interstitial cell of Cajal Gastric Emptying 030220 oncology & carcinogenesis symbols Female 030211 gastroenterology & hepatology Histopathology medicine.symptom business |
| Zdroj: | Neurogastroenterology & Motility. 29:e13068 |
| ISSN: | 1350-1925 |
| Popis: | Background The aims of this study were to describe the histology in gastroparesis, specifically to relate histopathology to etiology of gastroparesis (idiopathic and diabetic gastroparesis), gastric emptying, and clinical response to gastric electric stimulation. Methods Full thickness gastric body sections obtained during insertion of gastric stimulator in gastroparetics were stained with Hematoxylin & Eosin, Masson Trichrome and immunohistochemical stains for Neuron-Specific Enolase and c-Kit. Key Results In all, 145 gastroparetics (71 diabetics, 71 idiopathic, 2 post-surgical, and 1 chronic intestinal pseudo-obstruction) had full thickness gastric body biopsies. A lymphocytic infiltrate was seen in the intermyenteric plexus in 22 diabetic and 23 idiopathic gastroparesis patients. Fibrosis was present in the inner circular layer in 13 diabetic and 15 idiopathics and in the outer longitudinal layer in 46 diabetic and 51 idiopathics. Diabetic gastroparesis had less ganglion cells (3.27±1.82 vs 4.81±2.81/hpf; P |
| Databáze: | OpenAIRE |
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